Revista clinica espanola · 2025
Assessment of body fat distribution by ultrasound as a risk factor for mortality and readmission in patients admitted for sepsis.
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Algado-Rabasa J T, Ribes-Mengual I, Ronda-Perez E, Algado-Selles N
Аннотация
BACKGROUND: Sepsis is a serious condition with high mortality. Body fat can influence the production of inflammatory cytokines at the systemic level, leading to adverse outcomes; therefore, the distribution of body fat may have prognostic value. The objective is to evaluate whether there is a relationship between the distribution of body fat measured by ultrasound and prognosis in patients admitted with sepsis.
METHODS: A prospective cohort study was conducted in patients admitted for sepsis at a Spanish hospital between September 2023 and June 2024. The risk of mortality and readmission at 30 and 90 days was calculated based on the ratio of ultrasound measurements of subcutaneous fat (SAT) and visceral fat (VAT). The hazard ratio (HR) and 95% confidence interval for mortality and readmission were estimated based on the VAT/SAT ratio.
RESULTS: 62 patients were included. The median age was 77 years. The risk of mortality at 30 and 90 days post-admission was: for patients with VAT/SAT > 5.85, 18% and 35% respectively, and for patients with VAT/SAT < 5.85, 3% and 6.1%. The adjusted HR for mortality was 6.6 (95% CI: 1.4-30.6; p = 0.016). The risk of readmission at 30 and 90 days in patients with VAT/SAT > 8.03 was 46% and 80%, respectively, and in patients with VAT/SAT < 8.03, 23% and 30%. The HR for readmission was 3.1 (95% CI: 1.1-8.5; p = 0.026).
CONCLUSIONS: An increase in the VAT/SAT ratio, measured by ultrasound, is a risk factor for mortality and readmission in patients admitted for sepsis.
METHODS: A prospective cohort study was conducted in patients admitted for sepsis at a Spanish hospital between September 2023 and June 2024. The risk of mortality and readmission at 30 and 90 days was calculated based on the ratio of ultrasound measurements of subcutaneous fat (SAT) and visceral fat (VAT). The hazard ratio (HR) and 95% confidence interval for mortality and readmission were estimated based on the VAT/SAT ratio.
RESULTS: 62 patients were included. The median age was 77 years. The risk of mortality at 30 and 90 days post-admission was: for patients with VAT/SAT > 5.85, 18% and 35% respectively, and for patients with VAT/SAT < 5.85, 3% and 6.1%. The adjusted HR for mortality was 6.6 (95% CI: 1.4-30.6; p = 0.016). The risk of readmission at 30 and 90 days in patients with VAT/SAT > 8.03 was 46% and 80%, respectively, and in patients with VAT/SAT < 8.03, 23% and 30%. The HR for readmission was 3.1 (95% CI: 1.1-8.5; p = 0.026).
CONCLUSIONS: An increase in the VAT/SAT ratio, measured by ultrasound, is a risk factor for mortality and readmission in patients admitted for sepsis.