Terapevticheskii arkhiv · 2004
[Effect of long-term epidural analgesia and nitroglycerin infusion on formation of necrosis zone and clinical course of myocardial infarction].
Клиническое исследованиеКонтролируемое клиническое исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Tumak V N, Dzizinskiĭ A A
Аннотация
AIM: To study effects of long-term morphine-clofelin epidural analgesia and infusion of nitroglycerin on formation of the necrosis focus and the clinical course of acute myocardial infarction (MI).
MATERIAL AND METHODS: Ninety patients were examined within the first 12 hours of anterior macrofocal MI. Forty six patients of the study group received long-term morphine-clofelin epidural analgesia and nitroglycerine infusion within the first 24 hours of the disease. Forty-four control patients were anesthetized conventionally with intravenous morphine. Development of MI was assessed with electrocardiotopography and dynamic examination of MV CK in the blood serum.
RESULTS: The degree and area of the myocardial lesion were initially similar in the study and control groups. These indices were less in dynamics in the study group. On MI day 5 and 10 myocardial necrosis zone significantly diminished in the study group.
CONCLUSION: Long-term epidural analgesia and nitroglycerin infusion provide effective analgesia, localizes the ischemic and necrotic focus, have a good effect on hemodynamics and improve a MI clinical course.
MATERIAL AND METHODS: Ninety patients were examined within the first 12 hours of anterior macrofocal MI. Forty six patients of the study group received long-term morphine-clofelin epidural analgesia and nitroglycerine infusion within the first 24 hours of the disease. Forty-four control patients were anesthetized conventionally with intravenous morphine. Development of MI was assessed with electrocardiotopography and dynamic examination of MV CK in the blood serum.
RESULTS: The degree and area of the myocardial lesion were initially similar in the study and control groups. These indices were less in dynamics in the study group. On MI day 5 and 10 myocardial necrosis zone significantly diminished in the study group.
CONCLUSION: Long-term epidural analgesia and nitroglycerin infusion provide effective analgesia, localizes the ischemic and necrotic focus, have a good effect on hemodynamics and improve a MI clinical course.