Cureus · 2024
Allostatic Load and Oxidative Stress Markers in Women With Early- and Late-Onset Preeclampsia.
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Montoya-Estrada Araceli, García-Cerda María Valeria, Guzmán-Grenfell Alberto Martin, Figueroa-Damian Ricardo, Torres-Cosme José Luis, Laresgoiti-Servitje Estibalitz, Beltrán-Montoya Jesús Jorge, Romo-Yañez José, Reyes-Muñoz Enrique
Аннотация
BACKGROUND: Allostatic load and oxidative stress (OS) markers differ in women with and without preeclampsia. However, there is no difference in allostatic load and OS markers between late-onset preeclampsia (L-OP) and early-onset preeclampsia (E-OP). This study aimed to compare the concentrations of allostatic load and OS markers in pregnant women with L-OP and E-OP.
METHODS: This was a comparative cross-sectional study. Women with single pregnancy and a diagnosis of preeclampsia were included. Women with multiple pregnancies and/or chronic hypertension were excluded. Group 1 included women with E-OP (n=16), Group 2 included women with L-OP (n=45), and Group 3 included women without preeclampsia (n=40).
RESULTS: No statistical differences were found in maternal age, body mass index, or number of gestations. Arginase levels were higher in Group 1 compared to Group 2 (p = 0.04) and Group 1 compared to Group 3 (p = 0.01). Total antioxidative capacity was higher in Group 1 compared to Group 2 (p = 0.03) and Group 1 compared to Group 3 (p = 0.001). Malondialdehyde levels were higher in Group 1 compared to Group 2 (p = 0.001) and Group 1 compared to Group 3 (p = 0.001). Total sulfhydryl compounds were lower in Group 1 compared to Group 2 (p = 0.01) and Group 1 compared to Group 3 (p = 0.001). No differences were observed between study groups in allostatic load markers.
CONCLUSIONS: Higher levels of OS markers were found in women with E-OP compared to women with L-OP and controls.
METHODS: This was a comparative cross-sectional study. Women with single pregnancy and a diagnosis of preeclampsia were included. Women with multiple pregnancies and/or chronic hypertension were excluded. Group 1 included women with E-OP (n=16), Group 2 included women with L-OP (n=45), and Group 3 included women without preeclampsia (n=40).
RESULTS: No statistical differences were found in maternal age, body mass index, or number of gestations. Arginase levels were higher in Group 1 compared to Group 2 (p = 0.04) and Group 1 compared to Group 3 (p = 0.01). Total antioxidative capacity was higher in Group 1 compared to Group 2 (p = 0.03) and Group 1 compared to Group 3 (p = 0.001). Malondialdehyde levels were higher in Group 1 compared to Group 2 (p = 0.001) and Group 1 compared to Group 3 (p = 0.001). Total sulfhydryl compounds were lower in Group 1 compared to Group 2 (p = 0.01) and Group 1 compared to Group 3 (p = 0.001). No differences were observed between study groups in allostatic load markers.
CONCLUSIONS: Higher levels of OS markers were found in women with E-OP compared to women with L-OP and controls.