Journal of controlled release : official journal of the Controlled Release Society · 2018
Effect of obesity on biodistribution of nanoparticles.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Jesus Felismino Claudiana, Helal-Neto Edward, Portilho Filipe Leal, Rocha Pinto Suyene, Sancenón Félix, Martínez-Máñez Ramón, de Assis Ferreira Agatha, da Silva Simone Vargas, Barja-Fidalgo Thereza Christina, Santos-Oliveira Ralph
Аннотация
Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated two nanoparticles: magnetic core mesoporous silica (MSN) (58 nm) and polycaprolactone (PCL) nanoparticle (280 nm) in obese mice. Changes in the biodistribution were observed, especially considering the mononuclear phagocyte system (MPS), and the visceral fat tissue. Nonetheless, our data corroborates the influence of size in the biodistribution in obese animals, supporting that smaller nanoparticles, may show a higher tissue deposition at spleen, due the associated splenomegaly and the complications arising from this state. Finally, our study demonstrated that, in obesity, probably due the low-grade inflammatory state associated with metabolic syndrome a difference in accumulation of nanoparticles was found, with profound impact in the tissue deposition of nanoparticles.