Lung · 2026
Comparison Between EGFR-TKI Efficacy in Early-Stage Non-small Cell Lung Cancer and Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis.
СтатьяСистематический обзорМетаанализСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Bingxue, Yao Yang, Chen Zhangxuan, Wu Ranpu, Sun Jiajie, Li Xinjing, Xu Xuanhao, Si Yunxiao, Liu Hongbing
Аннотация
BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the standard of care for advanced non-small cell lung cancer (NSCLC). However, their comparative efficacy and safety profile in early-stage versus advanced-stage disease remains systematically unexplored.
METHODS: We performed a systematic review and meta-analysis of PubMed, Embase, Cochrane Library, and Web of Science through January 4, 2025. Included studies reported objective response rate (ORR), disease control rate (DCR), or treatment-related adverse events (TRAEs) for EGFR-TKI monotherapy. Pooled estimates were synthesized using a generalized linear mixed model (GLMM).
RESULTS: Forty-two studies comprising 46 treatment groups and 3713 patients (343 early-stage; 3370 advanced-stage) were included.
EFFICACY: The pooled ORR was significantly higher in advanced-stage NSCLC (0.59, 95% CI 0.51-0.67) than in early-stage disease (0.36, 95% CI 0.15-0.63). In contrast, early-stage disease achieved a higher DCR (0.95 vs. 0.89).
SAFETY: Early-stage patients experienced a significantly lower incidence of Grade ≥3 TRAEs compared to those with advanced disease (8.0% vs. 21%).
CONCLUSION: EGFR-TKIs provide superior tumor shrinkage (ORR) in advanced NSCLC, the reasons remain uncertain, whereas early-stage disease achieves better disease stability (DCR) with significantly enhanced tolerability. These findings suggest that stage-specific strategies-potentially combining TKIs with other modalities in early stages-are necessary to optimize clinical outcomes.
METHODS: We performed a systematic review and meta-analysis of PubMed, Embase, Cochrane Library, and Web of Science through January 4, 2025. Included studies reported objective response rate (ORR), disease control rate (DCR), or treatment-related adverse events (TRAEs) for EGFR-TKI monotherapy. Pooled estimates were synthesized using a generalized linear mixed model (GLMM).
RESULTS: Forty-two studies comprising 46 treatment groups and 3713 patients (343 early-stage; 3370 advanced-stage) were included.
EFFICACY: The pooled ORR was significantly higher in advanced-stage NSCLC (0.59, 95% CI 0.51-0.67) than in early-stage disease (0.36, 95% CI 0.15-0.63). In contrast, early-stage disease achieved a higher DCR (0.95 vs. 0.89).
SAFETY: Early-stage patients experienced a significantly lower incidence of Grade ≥3 TRAEs compared to those with advanced disease (8.0% vs. 21%).
CONCLUSION: EGFR-TKIs provide superior tumor shrinkage (ORR) in advanced NSCLC, the reasons remain uncertain, whereas early-stage disease achieves better disease stability (DCR) with significantly enhanced tolerability. These findings suggest that stage-specific strategies-potentially combining TKIs with other modalities in early stages-are necessary to optimize clinical outcomes.