Systemic inflammation response index (SIRI) predicts mortality and cardiovascular events in maintenance hemodialysis patients: A correlational study.

Maintenance hemodialysis (MHD) patients generally experience a state of micro-inflammation, which increases the risk of all-cause mortality and cardiovascular events (CVEs). The systemic inflammatory response index (SIRI) is a novel inflammatory marker that reflects the body's inflammatory state. Research has shown that SIRI not only serves as a prognostic indicator for many cancer-related diseases but also as a predictor for the occurrence of cardiovascular and cerebrovascular diseases. Currently, there is a paucity of research investigating the correlation between SIRI and all-cause mortality or the incidence of CVEs in patients undergoing MHD. This study is a retrospective cohort study, which collected 275 newly admitted MHD patients. The study population was divided into 2 groups based on the median value of SIRI. Kaplan-Meier cumulative incidence curves, multivariable logistic regression analysis, and competing risk model analysis were used to investigate the correlation between SIRI and all-cause mortality and CVE in MHD patients. Of all the patients, 275 cases of newly admitted MHD patients were recorded. Restricted cubic spline analysis revealed a linear association between the SIRI and all-cause morality as well as CVE. The Kaplan-Meier curves demonstrated differences in both all-cause mortality and CVE between the 2 groups. The competitive risk model suggested a significant difference in the cumulative incidence of all-cause mortality and CVE between the 2 groups. Compared to low SIRI group, adjusted Cox model showed that high SIRI group was associated with increased risk of all-cause mortality and CVE (all-cause mortality: odds ratio, 3.652; 95% confidence interval 1.812-7.363; P < .001; new-onset CVEs: odds ratio, 2.224; 95% confidence interval 1.191-4.155; P = .012). High SIRI levels are independent risk factors for all-cause mortality and CVEs in MHD patients.