Revista Argentina de microbiologia · 2026
Predictors of rectal carriage of carbapenemase-producing Gram-negative bacteria in general wards: A case-control study.
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Castro Maximiliano Gabriel, Sadonio María José, Vicino Macarena, Coduri Anthonioz Blanc Joaquín, Amato Ana Paula, Rottoli Erwin Alexander, Protto Manuel, Argarañá Fernanda, Galluccio Federico Rafael, Musacchio Héctor Mario, Gómez Sonia Alejandra
Аннотация
Rectal carriage of carbapenemase-producing Gram-negative bacteria (CP-GNB-RC) increases the risk of invasive infections and horizontal transmission. This study aimed to identify predictors of CP-GNB-RC in hospitalized patients. A case-control study was conducted in a 300-bed hospital in Santa Fe, Argentina, between 2022 and 2023. Cases and controls were randomly selected and included in a 1:2 ratio. A multivariate binary logistic regression model was built using variables significant in univariate analysis (p<0.05). Among 258 patients, 34.5% yielded at least one CP-GNB. Most isolates were Klebsiella spp. (79.0%) and 56.0% produced KPC. In the multivariate analysis, intensive care admission in the past 6 months (OR 3.61), patient transfer from another hospital (OR 2.89), antibiotic exposure (OR 2.34), and length of hospital stay (OR 1.05) were the only independent predictors of CP-GNB-RC. These findings may inform infection control strategies and antimicrobial stewardship interventions in our region.