Respiratory medicine · 2025
Prognostic significance of serum Mrp 8/14 in acute respiratory distress syndrome induced by pulmonary and extrapulmonary sepsis: A retrospective controlled study.
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Sun Caizhi, Li Ziqian, Guo Lei, Zhu Chenchen, Xu Bowen, Qin Haidong
Аннотация
BACKGROUND: To date, it remains unclear whether serum Mrp 8/14 is differentially expressed in sepsis-induced ARDS patients of pulmonary and extrapulmonary origin during ICU hospitalization. This study investigated the association between serum Mrp 8/14 and clinical outcomes in sepsis-induced ARDS patients.
METHODS: A retrospective, single-center cohort study was conducted involving 153 septic patients who developed ARDS during their ICU stay, resulting from either pulmonary or extrapulmonary infections. The enrolled patients were further stratified into survivor and non-survivor groups based on ICU mortality.
MAIN FINDINGS: The serum Mrp 8/14 on the first day of ICU admission was detected. The expression of serum Mrp 8/14 in pulmonary ARDS was 15.91 (10.32, 23.48)ug/ml, which was significantly higher compared to that of the extrapulmonary ARDS at 9.51 (4.55, 16.98)ug/ml (p = 0.000). The logistic regression analysis revealed that serum Mrp 8/14 was the independent factor associated with the mortality in sepsis-induced pulmonary ARDS (OR = 1.223, 95 % CI 1.105-1.375, p = 0.000). The areas under the receiver operating characteristic curves for serum Mrp 8/14 was associated with ICU mortality in patients with pulmonary ARDS (AUC = 0.872, 95 %CI 0.798-0.947, p = 0.000). The Kaplan-Meier curve demonstrated a significantly higher survival rate among pulmonary ARDS patients with serum Mrp 8/14 levels below 19.23 μg/ml compared to those with serum Mrp 8/14 levels above this threshold (HR = 3.480, 95 % CI = 1.819-6.659, p = 0.000).
CONCLUSIONS: Serum Mrp 8/14 levels upon ICU admission may serve as a valuable prognostic indicator for predicting the mortality in patients with sepsis-induced pulmonary ARDS during ICU hospitalization.
METHODS: A retrospective, single-center cohort study was conducted involving 153 septic patients who developed ARDS during their ICU stay, resulting from either pulmonary or extrapulmonary infections. The enrolled patients were further stratified into survivor and non-survivor groups based on ICU mortality.
MAIN FINDINGS: The serum Mrp 8/14 on the first day of ICU admission was detected. The expression of serum Mrp 8/14 in pulmonary ARDS was 15.91 (10.32, 23.48)ug/ml, which was significantly higher compared to that of the extrapulmonary ARDS at 9.51 (4.55, 16.98)ug/ml (p = 0.000). The logistic regression analysis revealed that serum Mrp 8/14 was the independent factor associated with the mortality in sepsis-induced pulmonary ARDS (OR = 1.223, 95 % CI 1.105-1.375, p = 0.000). The areas under the receiver operating characteristic curves for serum Mrp 8/14 was associated with ICU mortality in patients with pulmonary ARDS (AUC = 0.872, 95 %CI 0.798-0.947, p = 0.000). The Kaplan-Meier curve demonstrated a significantly higher survival rate among pulmonary ARDS patients with serum Mrp 8/14 levels below 19.23 μg/ml compared to those with serum Mrp 8/14 levels above this threshold (HR = 3.480, 95 % CI = 1.819-6.659, p = 0.000).
CONCLUSIONS: Serum Mrp 8/14 levels upon ICU admission may serve as a valuable prognostic indicator for predicting the mortality in patients with sepsis-induced pulmonary ARDS during ICU hospitalization.