Serum calcium concentrations and incidence of hypocalcemia in infants with moderate or severe hypoxic-ischemic encephalopathy: Effect of therapeutic hypothermia.

BACKGROUND

Hypocalcemia is a common morbidity in asphyxiated infants. Therapeutic hypothermia (TH), the standard of care for infants with moderate and severe hypoxic-ischemic encephalopathy (HIE), promotes neuroprotection by several mechanisms including a decrease in intracellular calcium (Ca(2+)) influx which may improve serum Ca(2+) levels and homeostasis.

AIMS: To evaluate the impact of TH on Ca(2+) homeostasis.

STUDY

DESIGN

Historical, retrospective cohort analysis.

SUBJECTS: Infants with moderate or severe HIE admitted to the hospital with≤24hours of age, gestational age≥36weeks, and birth weight ≥1800g, before (pre-TH) and after (post-TH) TH was implemented.

OUTCOME MEASURES: Minimum and maximum serum levels of ionized Ca(2+) (iCa(2+)) and magnesium (Mg), Ca(2+) and Mg intakes, and incidence of hypo/hypercalcemia during the first week of life.

RESULTS

A total of 67 infants were included: 29 pre-TH and 38 post-TH. Minimum iCa(2+)levels were significantly lower in the pre-TH group; some infants required Ca(2+) boluses infusions. In the post-TH group, a significantly lower intake of Ca(2+) was necessary to maintain normal Ca(2+) levels and no infant required boluses. The incidence of hypocalcemia was higher in the pre-TH group with a statistically significant difference on day 2 of life (18 vs 0%; p=0.01).

CONCLUSIONS

After the implementation of TH, iCa(2+) levels were within normal ranges despite lower Ca(2+) intakes. A lower incidence of hypocalcemia was observed during cooling. Our findings support the hypothesis that TH improves Ca(2+) homeostasis in HIE infants.