MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression.

OBJECTIVES

We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI).

METHODS

We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98).

RESULTS

The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p < 0.001) compared with the patients with MDD without SI and the healthy controls.

CONCLUSIONS

Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.