Romanian journal of ophthalmology · 2026
Innovations in Corneal Transplantation: The Role of Eye Banks, Donor Corneas, and Artificial Alternatives in Combating Worldwide Corneal Blindness.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chandra Mahesh, Singh Jitendra, Dubey Gaurav, Pandey Govind Gaurav, Jha Ayush
Аннотация
AIM: Corneal disorders-including degeneration, dystrophy, infection, and inflammation-rank as the fifth leading cause of global visual impairment. In developing regions, conditions such as trachoma and xerophthalmia further increase this burden. This review explores the current landscape, challenges, and advancements in corneal blindness management, with a focus on the role of eye banks and keratoplasty techniques.
OBJECTIVES: (i) Assess global burden and causes of corneal blindness; (ii) Highlight eye banks' roles in donor tissue management; (iii) Identify challenges in eye banking and transplantation; (iv) Evaluate keratoplasty procedures; (v) Examine surgical innovations and therapies such as corneal collagen cross-linking.
METHODOLOGY: A comprehensive literature review was conducted, analyzing peer-reviewed publications, health reports, and clinical guidelines. Data from both developed and developing countries were considered to provide a holistic perspective.
DISCUSSION: Corneal transplantation remains the most effective treatment for advanced corneal blindness; however, a significant gap persists between the demand for donor corneas and their availability. Advances in preservation techniques and the shift toward lamellar keratoplasty have improved graft survival and visual outcomes. Nevertheless, limited donor awareness and infrastructural constraints continue to affect successful implementation.
CONCLUSION: Advanced keratoplasty methods-Penetrating Keratoplasty, Deep Anterior Lamellar Keratoplasty, and Endothelial Keratoplasty-have improved outcomes by reducing rejection and accelerating recovery. The adoption of femtosecond laser technology has enhanced surgical precision. Corneal collagen cross-linking now offers a minimally invasive option to delay or prevent transplant in ectatic conditions. Despite these advancements, global eye banks face persistent challenges in donor recruitment, tissue preservation, and ethical management. Continued innovation, improved infrastructure, and strengthened public health efforts are crucial to overcoming these barriers and reducing the global burden of corneal blindness.
OBJECTIVES: (i) Assess global burden and causes of corneal blindness; (ii) Highlight eye banks' roles in donor tissue management; (iii) Identify challenges in eye banking and transplantation; (iv) Evaluate keratoplasty procedures; (v) Examine surgical innovations and therapies such as corneal collagen cross-linking.
METHODOLOGY: A comprehensive literature review was conducted, analyzing peer-reviewed publications, health reports, and clinical guidelines. Data from both developed and developing countries were considered to provide a holistic perspective.
DISCUSSION: Corneal transplantation remains the most effective treatment for advanced corneal blindness; however, a significant gap persists between the demand for donor corneas and their availability. Advances in preservation techniques and the shift toward lamellar keratoplasty have improved graft survival and visual outcomes. Nevertheless, limited donor awareness and infrastructural constraints continue to affect successful implementation.
CONCLUSION: Advanced keratoplasty methods-Penetrating Keratoplasty, Deep Anterior Lamellar Keratoplasty, and Endothelial Keratoplasty-have improved outcomes by reducing rejection and accelerating recovery. The adoption of femtosecond laser technology has enhanced surgical precision. Corneal collagen cross-linking now offers a minimally invasive option to delay or prevent transplant in ectatic conditions. Despite these advancements, global eye banks face persistent challenges in donor recruitment, tissue preservation, and ethical management. Continued innovation, improved infrastructure, and strengthened public health efforts are crucial to overcoming these barriers and reducing the global burden of corneal blindness.