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Войти в исследования Cell reports · 2024
Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yonemura Atsuko, Semba Takashi, Zhang Jun, Fan Yibo, Yasuda-Yoshihara Noriko, Wang Huaitao, Uchihara Tomoyuki, Yasuda Tadahito, Nishimura Akiho, Fu Lingfeng, Hu Xichen, Wei Feng, Kitamura Fumimasa, Akiyama Takahiko, Yamashita Kohei, Eto Kojiro, Iwagami Shiro, Iwatsuki Masaaki, Miyamoto Yuji, Matsusaki Keisuke, Yamasaki Juntaro, Nagano Osamu, Saya Hideyuki, Song Shumei, Tan Patrick, Baba Hideo, Ajani Jaffer A, Ishimoto Takatsugu
Аннотация
Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a comprehensive proteomic analysis are conducted to comprehensively characterize malignant ascites. Here, we find defects in immune effectors along with immunosuppressive cell accumulation in ascites of patients with gastric cancer (GC) and identify five distinct subpopulations of CD45(-)/EpCAM(-) cells. Mesothelial cells with mesenchymal features in CD45(-)/EpCAM(-) cells are the predominant source of chemokines involved in immunosuppressive myeloid cell (IMC) recruitment. Moreover, mesothelial-mesenchymal transition (MMT)-induced mesothelial cells strongly express extracellular matrix (ECM)-related genes, including tenascin-C (TNC), enhancing metastatic colonization. These findings highlight the definite roles of the mesenchymal cell population in the development of a protumorigenic microenvironment to promote peritoneal dissemination.