Noise-induced hearing damage caused by metabolic exhaustion: a mathematical model.

A mathematical model for noise-induced hearing loss is based on the assumption that hair cells are damaged, temporarily or permanently, by metabolic exhaustion, and that the number of damaged hair cells and the hearing loss are monotonically increasing functions of an energy deficiency. The purpose of the model is to focus on the influence of sound intensity, exposure duration, and temporal pattern of the sound exposure on the noise-induced hearing loss from long-duration exposures. The model is restricted to the range of sound levels where metabolic exhaustion probably is the main reason for the hair cell damage. Only exposures with similar frequency spectra and producing moderate hearing losses are considered; frequency dependence is not discussed.