[Dynamics of folliculogenesis in the mouse ovary after the intrauterine elimination of germ cells by administering cyclophosphamide].

Injection of cytostatic--cyclophosphamide--to pregnant mice produces elimination of germ cells in their offspring ovaries. Independently on the elimination degree of the germ cells, the amount of growing follicles, as well as dynamics of their growth do not differ from those in the majority of control (intact) animals. In some cases the delay in the rate of the follicular growth is connected with regional outgrowth of the interstitial tissue. This, in its turn, depends on uneven distribution of the germ cells, preserved after cyclophosphamide effect. Unlike the control, for the experimental animals ovaries it is normal that the amount of the growing follicles predominates over the nongrowing ones. This results in exhaustion of the germ cells population and in further sterility. The results obtained contradict the universally recognized data that the process of initiation of the follicular growth depends on the number of the nongrowing follicles. The cause disturbing this dependence is, evidently, certain change in the balance of germ and somatic cells in the ovary development, produced by injection of cyclophosphamide.