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DOI 10.1101/2024.09.20.24313635

Медицинская библиотека · medRxiv : the preprint server for health sciences · 2024

Characterizing trachoma elimination using serology.

Kamau Everlyn, Ante-Testard Pearl Anne, Gwyn Sarah, Blumberg Seth, Abdalla Zeinab, Aiemjoy Kristen, Amza Abdou, Aragie Solomon, Arzika Ahmed M, Awoussi Marcel S, Bailey Robin L, Butcher Robert, Callahan E Kelly, Chaima David, Dawed Adisu Abebe, Saboyá Díaz Martha Idalí, Domingo Abou-Bakr Sidik, Drakeley Chris, Elshafie Belgesa E, Emerson Paul M, Fornace Kimberley, Gass Katherine, Goodhew E Brook, Hammou Jaouad, Harding-Esch Emma M, Hooper P J, Kadri Boubacar, Kalua Khumbo, Kanyi Sarjo, Kasubi Mabula, Kello Amir B, Ko Robert, Lammie Patrick J, Lescano Andres G, Maliki Ramatou, Masika Michael Peter, Migchelsen Stephanie J, Nassirou Beido, Nesemann John M, Parameswaran Nishanth, Pomat Willie, Renneker Kristen, Roberts Chrissy, Rymil Prudence, Sata Eshetu, Senyonjo Laura, Seife Fikre, Sillah Ansumana, Sokana Oliver, Srivathsan Ariktha, Tadesse Zerihun, Taleo Fasihah, Taylor Emma Michelle, Tekeraoi Rababe, Togbey Kwamy, West Sheila K, Wickens Karana, William Timothy, Wittberg Dionna M, Yeboah-Manu Dorothy, Youbi Mohammed, Zeru Taye, Keenan Jeremy D, Lietman Thomas M, Solomon Anthony W, Nash Scott D, Martin Diana L, Arnold Benjamin F

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Аннотация

Trachoma is targeted for global elimination as a public health problem by 2030. Measurement of IgG antibodies in children is being considered for surveillance and programmatic decision-making. There are currently no guidelines for applications of serology, which represents a generalizable problem in seroepidemiology and disease elimination. We collated Chlamydia trachomatis Pgp3 and CT694 IgG measurements (63,911 children ages 1-9 years) from 48 serosurveys, including surveys across Africa, Latin America, and the Pacific Islands to estimate population-level seroconversion rates (SCR) along a gradient of trachoma endemicity. We propose a novel, generalizable approach to estimate the probability that population C. trachomatis transmission is below levels requiring ongoing programmatic action, or conversely is above levels that indicate ongoing interventions are needed. We provide possible thresholds for SCR at a specified level of certainty and illustrate how the approach could be used to inform trachoma program decision-making using serology.

Для цитирования: Kamau Everlyn, Ante-Testard Pearl Anne, Gwyn Sarah, Blumberg Seth, Abdalla Zeinab, Aiemjoy Kristen, Amza Abdou, Aragie Solomon, Arzika Ahmed M, Awoussi Marcel S, Bailey Robin L, Butcher Robert, Callahan E Kelly, Chaima David, Dawed Adisu Abebe, Saboyá Díaz Martha Idalí, Domingo Abou-Bakr Sidik, Drakeley Chris, Elshafie Belgesa E, Emerson Paul M, Fornace Kimberley, Gass Katherine, Goodhew E Brook, Hammou Jaouad, Harding-Esch Emma M, Hooper P J, Kadri Boubacar, Kalua Khumbo, Kanyi Sarjo, Kasubi Mabula, Kello Amir B, Ko Robert, Lammie Patrick J, Lescano Andres G, Maliki Ramatou, Masika Michael Peter, Migchelsen Stephanie J, Nassirou Beido, Nesemann John M, Parameswaran Nishanth, Pomat Willie, Renneker Kristen, Roberts Chrissy, Rymil Prudence, Sata Eshetu, Senyonjo Laura, Seife Fikre, Sillah Ansumana, Sokana Oliver, Srivathsan Ariktha, Tadesse Zerihun, Taleo Fasihah, Taylor Emma Michelle, Tekeraoi Rababe, Togbey Kwamy, West Sheila K, Wickens Karana, William Timothy, Wittberg Dionna M, Yeboah-Manu Dorothy, Youbi Mohammed, Zeru Taye, Keenan Jeremy D, Lietman Thomas M, Solomon Anthony W, Nash Scott D, Martin Diana L, Arnold Benjamin F. Characterizing trachoma elimination using serology.. medRxiv : the preprint server for health sciences. 2024. DOI: 10.1101/2024.09.20.24313635.
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