Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019
Disseminated thymic B-cell lymphoma in a Holstein heifer.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Hishamnuri Wan N A D, Nakagun Shotaro, Maezawa Masaki, Sakaguchi Kana, Akiyama Nao, Watanabe Ken-Ichi, Horiuchi Noriyuki, Kobayashi Yoshiyasu, Inokuma Hisashi
Аннотация
A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.