Медицинская библиотека · BMC cancer · 2016

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.

Kasuga Jun, Kawahara Takashi, Takamoto Daiji, Fukui Sachi, Tokita Takashi, Tadenuma Tomoyuki, Narahara Masaki, Fusayasu Syusei, Terao Hideyuki, Izumi Koji, Ito Hiroki, Hattori Yusuke, Teranishi Jun-Ichi, Sasaki Takeshi, Makiyama Kazuhide, Miyoshi Yasuhide, Yao Masahiro, Yumura Yasushi, Miyamoto Hiroshi, Uemura Hiroji

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer.

METHODS

A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer.

RESULTS

The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR.

CONCLUSIONS

The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.

Для цитирования: Kasuga Jun, Kawahara Takashi, Takamoto Daiji, Fukui Sachi, Tokita Takashi, Tadenuma Tomoyuki, Narahara Masaki, Fusayasu Syusei, Terao Hideyuki, Izumi Koji, Ito Hiroki, Hattori Yusuke, Teranishi Jun-Ichi, Sasaki Takeshi, Makiyama Kazuhide, Miyoshi Yasuhide, Yao Masahiro, Yumura Yasushi, Miyamoto Hiroshi, Uemura Hiroji. Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.. BMC cancer. 2016. DOI: 10.1186/s12885-016-2443-6.

Предметные рубрики MeSH

Aged Aged, 80 and over Area Under Curve Carcinoma, Squamous Cell Humans Lymphocyte Count Male Middle Aged Neoplasm Staging Neutrophils Penile Neoplasms Prognosis ROC Curve Survival Analysis

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