Influence of oxidative stress caused by a blast wave in acoustic barotrauma on the auditory analyzer.

OBJECTIVE

Aim: To determine the intensity of posttraumatic oxidative stress (OS) in patients with mild explosive traumatic brain injury (METBI) complicated by acoustic barotrauma and its association with sensorineural hearing loss (SHL) occurrence.

PATIENTS AND

METHODS

Materials and

Methods

This study included 43 patients with METBI form October 2023 to May 2024.

RESULTS

Results

METBI initiated an increase in OS markers in blood: aldehyde phenylhydrazone (APH) by 53.54% (p<0.05), carboxy phenylhydrazone (CPH) - by 50.51% (p<0.05) and with a deficiency of the antioxidant system of reduced glutathione by 47.4% (p<0.05), total thiols by 61.7% (p<0.05), decrease in the level of nitric oxide in blood by 54.22% (p<0.05), which led to microcirculatory disorder. A direct correlation was established between the frequency of SHL and an increase of APH (r=+0.72, p<0.05), CPH (r=+0.66, p<0.05) and an inverse correlation with a reduced glutathione deficiency (r=-0.85, p<0.05).

CONCLUSION

Conclusions

An imbalance of antioxidant protection led to significant microcirculatory disorders. The data obtained are important for the neutralization of the effect of damaging factors of OS on thе inner ear microcirculation.