Renal failure · 2008
Frequency and clinical profile of patients with polycystic kidney disease in southern Brazil.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Nunes Ane Cláudia Fernandes, Milani Vagner, Porsch Daiana Benck, Rossato Liana Bertolin, Mattos Cristiane Bastos, Roisenberg Israel, Barros Elvino José Guardão
Аннотация
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic nephropathies, affecting one in every 800-1000 individuals in the worldwide general population and 5-10% of hemodialysis patients. Little data concerning the prevalence of ADPKD in Brazil are available. Thus, the aim of the present study was to investigate both the frequency and clinical profile of ADPKD among hemodialysis patients in south of Brazil.
METHODS: This cross-sectional study consisted of patients from 24 hemodialysis centers. Patients were screened for ADPKD by clinical, laboratorial, and image examination in medical records.
RESULTS: Of 1326 patients on hemodialysis in the south of Brazil that composed this study, 99 (7.5%) had polycystic kidney as primary cause for chronic renal failure. Comparisons between ADPKD and non-ADPKD patients revealed no differences regarding mean age, gender, and ethnicity.
CONCLUSIONS: Our data revealed that ADPKD is prevalent among patients on hemodialysis in the south of Brazil. In addition, the clinical profile of ADPKD is similar to reported data from North America and Europe, putatively due to the similar ethnic composition mainly based on European descents.
METHODS: This cross-sectional study consisted of patients from 24 hemodialysis centers. Patients were screened for ADPKD by clinical, laboratorial, and image examination in medical records.
RESULTS: Of 1326 patients on hemodialysis in the south of Brazil that composed this study, 99 (7.5%) had polycystic kidney as primary cause for chronic renal failure. Comparisons between ADPKD and non-ADPKD patients revealed no differences regarding mean age, gender, and ethnicity.
CONCLUSIONS: Our data revealed that ADPKD is prevalent among patients on hemodialysis in the south of Brazil. In addition, the clinical profile of ADPKD is similar to reported data from North America and Europe, putatively due to the similar ethnic composition mainly based on European descents.
Предметные рубрики MeSH
AdultAge DistributionAnalysis of VarianceBrazilCross-Sectional StudiesFemaleHumansIncidenceKidney Failure, ChronicKidney Function TestsMaleMiddle AgedMulticenter Studies as TopicPolycystic Kidney, Autosomal DominantProbabilityPrognosisRenal DialysisRisk AssessmentSeverity of Illness IndexSex DistributionStatistics, NonparametricSurvival AnalysisTreatment Outcome