Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies.

Objective

To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation.

Methods

We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients.

Results

The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = -0.546, p = .0.001) and composite adverse obstetric outcome (r = -0.415, p = .0.018).

Conclusion

The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.