The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2012
Outcome of twin pregnancy in women ≥45 years old: a retrospective cohort study.
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Laskov I, Michaan N, Cohen A, Tsafrir Z, Maslovitz S, Kupferminc M, Lessing Jb, Many A
Аннотация
OBJECTIVE: To investigate prematurity rate in women aged ≥45 carrying a twin pregnancy. Other maternal and neonatal outcomes are also described.
DESIGN: Retrospective cohort study.
SETTING: Women delivering a twin pregnancy at a single tertiary medical center.
POPULATION: The study included all women aged 45 years and over carrying a twin pregnancy who delivered at 20 weeks gestation or beyond over a 9-year period from May 2000 to May 2009.
METHODS: Women aged 45 years and over were identified, all conceived by in vitro fertilization with ovum donation. The study group was compared to a control group of women <40 years with twin pregnancies conceived by IVF who delivered during the same time period.
MAIN OUTCOME MEASURE(S): Maternal complications during pregnancy and neonatal outcome.
RESULTS: During the study period 32 women ≥45 years delivered twins. The control group included 109 women. The rate of delivery before 37 weeks as well as before 32 weeks were very high in our study group (65% versus 40%, p = 0.01 and 15% versus 5.0%, p = 0.05, respectively). The rate of maternal life-threatening complications including blood product transfusion and maternal admission to the intensive care unit were also significantly higher in our study group compared to the control group (18% versus 2%, p = 0.018 and 6.3% versus none, p = 0.05).
CONCLUSIONS: Women ≥45 years old with twin pregnancy carry a higher risk of maternal and perinatal complications.
DESIGN: Retrospective cohort study.
SETTING: Women delivering a twin pregnancy at a single tertiary medical center.
POPULATION: The study included all women aged 45 years and over carrying a twin pregnancy who delivered at 20 weeks gestation or beyond over a 9-year period from May 2000 to May 2009.
METHODS: Women aged 45 years and over were identified, all conceived by in vitro fertilization with ovum donation. The study group was compared to a control group of women <40 years with twin pregnancies conceived by IVF who delivered during the same time period.
MAIN OUTCOME MEASURE(S): Maternal complications during pregnancy and neonatal outcome.
RESULTS: During the study period 32 women ≥45 years delivered twins. The control group included 109 women. The rate of delivery before 37 weeks as well as before 32 weeks were very high in our study group (65% versus 40%, p = 0.01 and 15% versus 5.0%, p = 0.05, respectively). The rate of maternal life-threatening complications including blood product transfusion and maternal admission to the intensive care unit were also significantly higher in our study group compared to the control group (18% versus 2%, p = 0.018 and 6.3% versus none, p = 0.05).
CONCLUSIONS: Women ≥45 years old with twin pregnancy carry a higher risk of maternal and perinatal complications.