International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2018
Two cases of disseminated infection following live organism anti-cancer vaccine administration in cancer patients.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Denham James D, Lee Dae Hyun, Castro Manuel, Pandya Shuchi, Aslam Sadaf, Nanjappa Sowmya, Greene John N
Аннотация
Vaccines containing live attenuated bacterial or viral organisms are currently being investigated as potential therapy for locally advanced or metastatic cancers. However, the use of such live organisms in an immunocompromised population, such as patients who recently or are currently receiving chemotherapy, raises the concern that these organisms can themselves disseminate and cause frank infection. We report a hereunto unreported phenomenon of anti-cancer vaccines (containing live attenuated organisms) leading to frank, disseminated infection. We submit that occurrence of this phenomenon must be watched for by all members of the interdisciplinary cancer treatment team.