Hemostatic and metabolic variables in women with polycystic ovary syndrome.

OBJECTIVE

To study whether a previously demonstrated increased morbidity in cardiovascular disease (CVD) and diabetes mellitus in women with polycystic ovary syndrome (PCOS) is associated with certain hemostatic variables that are known to be markers for CVD.

DESIGN

The study was a trans-sectional follow-up study from a cohort of women with PCOS.

SETTING

The women with PCOS were recruited from hospital clinics and referents were randomized from a population study of women from the same area.

PARTICIPANTS

The investigation involved 28 women aged 43 to 62 years diagnosed to have PCOS on ovarian histopathology at wedge resection 25 to 34 years previously and 56 referents who were matched by age and body mass index.

MAIN OUTCOME MEASURES: In connection with a clinical investigation, the hemostatic variables fibrinogen, von Willebrand factor antigen, factor VII procoagulant activity, factor VII antigen, and plasminogen activator inhibitor as well as the metabolic variables serum insulin and serum triglycerides were assayed.

RESULTS

There was a strong positive correlation between serum concentrations of triglyceride, basal insulin, and abdominal obesity on the one hand, and plasminogen activator inhibitor, fibrinogen, and von Willebrand factor on the other, among women with PCOS as well as among referents. There were significantly higher mean concentrations of fibrinogen and factor VII:Ag among referents, but the mean values of most hemostatic variables studied showed no differences between the groups.

CONCLUSION

Women with an altered metabolic profile were also found to have affected hemostatic factors, but PCOS in itself did not seem to influence them.