Association between periodontal inflamed surface area and estimated glomerular filtration rate among pre-dialysis chronic kidney disease patients.

INTRODUCTION

periodontitis increases systemic inflammatory burden and the effect of this could be worsening renal function of chronic kidney disease patients (CKD). The purpose of this study was to evaluate the relationship between renal function and periodontal inflammation among CKD population attending a tertiary institution in Nigeria.

METHODS

a total of 120 pre-dialysis CKD patients were enrolled in this study and their serum creatinine level was measured for the estimation of glomerular filtration rate (eGFR). The burden of periodontal inflammation was evaluated using periodontal inflamed surface area (PISA). Simple and Multiple linear regression analysis was done to explain the relationship between renal function and periodontal inflammation.

RESULTS

a total number of 120 participants, made up of 68 (56.7%) males and 52 (43.3%) females diagnosed of chronic kidney disease (CKD). On simple and multiple linear regression analysis, PISA was significantly associated with eGFR (β = -0.017, 95% CI -0.026 to -0.009; P < 0.001). Pearson correlation analysis also suggested a moderate correlation between PISA and eGFR (r=-0.5, p<0.001).

CONCLUSION

this study suggests that renal function and periodontal inflammation might be related, increasing the severity of periodontitis, which could possibly lead to decreased renal function.