Natural product research · 2021
Phytochemical investigation and biological activity of Doronicum pardalianches L. roots against Alzheimer's disease.
СтатьяНазвание и аннотация: Перевод в очереди
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Manayi Azadeh, Rastegari Arezoo, Heydarian Bita, Vahedi-Mazdabadi Yasaman, Khanavi Mahnaz, Akbarzadeh Tahmineh, Saeedi Mina
Аннотация
The methanol extract of Doronicum pardalianches L. was fractionated using n-hexane, chloroform, and ethyl acetate to evaluate their cholinesterase (ChE) inhibitory activity via modified Ellman's method. It was perceived that only the ethyl acetate fraction was active toward acetylcholinesterase (AChE) with IC50 value of 172.21 µg/mL. Also, all fractions showed no butyrylcholinesterase (BChE) inhibitory activity. The ethyl acetate fraction was also investigated for its neuroprotectivity and metal chelating ability (Zn2+, Fe2+, and Cu2+) which demonstrated desired activity. Phytochemical analysis of the ethyl acetate fraction led to isolation and identification of formononetin 7-O-β-D-glucopyranoside which has not been previously reported for this plant.