Nature microbiology · 2025
Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Phan-Canh Trinh, Coman Cristina, Lackner Michaela, Troppmair Nina, Müller Christoph, Cerbu Diana, Seiser Saskia, Penninger Philipp, Tsymala Irina, Khunweeraphong Narakorn, Bitencourt Tamires, Knarr Andrej, Jenull Sabrina, Arzani Hossein, Zenz Lisa-Maria, Ianiri Giuseppe, Chen Weiqiang, Chowdhary Anuradha, Mobley Harry L T, Hartl Markus, Moser Doris, Ahrends Robert, Elbe-Bürger Adelheid, Kuchler Karl
Аннотация
The pronounced skin tropism and pan-antifungal resistance of Candida auris pose a serious global health threat. A key question in C. auris biology is how clinical isolates acquire amphotericin B resistance. Here we demonstrate that a carbonic sensing pathway (CSP) contributes to amphotericin B resistance by modulating mitochondrial energy functions in clinical C. auris isolates. Integrated transcriptomics and proteomics identify the carbonic anhydrase Nce103 and its transcription factors Rca1 and Efg1 as important regulatory components of the CSP. The conversion of CO2 into bicarbonate sustains energy metabolism required for colonization and fitness on human skin and in nutrient-limited microenvironments. We also show that bacterial skin colonizers engage urease to release CO2 that sustains C. auris fitness and skin colonization. These findings highlight therapeutic options to re-sensitize C. auris to antifungal treatments, as well as to prevent skin colonization by blocking the CSP.