American journal of reproductive immunology (New York, N.Y. : 1989) · 2002
T-cell cytokines in pregnancy.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Piccinni Marie-Pierre
Аннотация
PROBLEM: Immunological mechanisms induced by T cells may play an important role in preimplantation embryo development, in implantation process and in the phenomenon of fetal allograft tolerance.
METHODS: We review existing data on the role of T cells in pregnancy.
RESULTS: The production of LIF, interleukin (IL)-4, IL-10 and M-CSF by the decidual T cells may contribute to the maintenance of pregnancy. T cells are not only confined to the uterus. T cells are also present in cumulus oophorus and are able to produce LIF and IL-4.
CONCLUSIONS: These findings may provide an initial cue in favor of the possibility that different cytokines produced by T cells acting in concert are required to create a suitable microenvironment for the preimplantation embryo development and for the maintenance of pregnancy. T cells could work in parallel with other cells present in the decidua and cumulus suggesting a complex network of hormones, cytokines and cells.
METHODS: We review existing data on the role of T cells in pregnancy.
RESULTS: The production of LIF, interleukin (IL)-4, IL-10 and M-CSF by the decidual T cells may contribute to the maintenance of pregnancy. T cells are not only confined to the uterus. T cells are also present in cumulus oophorus and are able to produce LIF and IL-4.
CONCLUSIONS: These findings may provide an initial cue in favor of the possibility that different cytokines produced by T cells acting in concert are required to create a suitable microenvironment for the preimplantation embryo development and for the maintenance of pregnancy. T cells could work in parallel with other cells present in the decidua and cumulus suggesting a complex network of hormones, cytokines and cells.