Birth defects research. Part A, Clinical and molecular teratology · 2003
Malformations following methimazole exposure in utero: an open issue.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ferraris Silvio, Valenzise Mariella, Lerone Margherita, Divizia Maria Teresa, Rosaia Lucia, Blaid Dario, Nemelka Odette, Ferrero Giovanni Battista, Silengo Margherita
Аннотация
BACKGROUND: In hyperthyroidism-complicated pregnancies, medical therapy is necessary to reach an euthyroid condition, and propylthiouracil (PTU) or methimazole (MMI) are used. These drugs are equally effective, but may cause fetal and neonatal hypothyroidism because they freely cross the placenta. Although PTU has not been significantly associated with embryo-fetal anomalies, it has been suggested that MMI might be responsible for a specific embryopathy.
CASE(S): Two cases of major congenital anomalies after MMI exposure during pregnancy are reported.
CONCLUSIONS: PTU should be the drug of choice, and the use of MMI should be restricted to cases with allergic reactions, intolerance, or poor response to PTU.
CASE(S): Two cases of major congenital anomalies after MMI exposure during pregnancy are reported.
CONCLUSIONS: PTU should be the drug of choice, and the use of MMI should be restricted to cases with allergic reactions, intolerance, or poor response to PTU.