[Dynamics of homocytotropic antibody production in pigs].

Homocytotropic antibody (HTA) production in pigs was stimulated by sensitization with alum precipitated equine serum or with equine serum in Freund's complete adjuvant. Two doses of appropriate antigen were given in 7 days interval simultaneously with heat inactivated suspension of Bordetella pertussis organisms. HTA were detected in 6 of 10 pigs sensitized with alum precipitated serum and in 4 of 6 pigs sensitized with serum in Freund's complete adjuvant. In pigs sensitized with alum precipitated serum HTA appeared at day 6 after the first antigen administration. In pigs sensitized with serum in Freund's complete adjuvant HTA appeared at day 18 after the first antigen administration. Time course of appearance of HTA was about 10 days in both groups. Alum precipitated serum elicited considerably higher titres of HTA than equine serum in Freund's complete adjuvant. The passive cutaneous anaphylaxis activity of the HTA sera was located in the 7S fraction.