[Rinsho ketsueki] The Japanese journal of clinical hematology · 2020
[Vacuolar myelopathy after allogeneic bone marrow transplantation in a patient with acute lymphoblastic leukemia].
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kumagai Takuma, Doki Noriko, Kobayashi Takeshi, Yamada Rin, Hishima Tsunekazu, Adachi Hiroto, Konuma Ryosuke, Fujita Masahiro, Wada Atsushi, Kishida Yuya, Konishi Tatsuya, Nagata Akihito, Yamada Yuta, Kaito Satoshi, Yoshifuji Kota, Mukae Junichi, Akiyama Megumi, Inamoto Kyoko, Toya Takashi, Igarashi Aiko, Najima Yuho, Kakihana Kazuhiko, Sakamaki Hisashi, Ohashi Kazuteru
Аннотация
Vacuolar myelopathy (VM) is known to be a neurological complication in patients with acquired immunodeficiency syndrome (AIDS). In autopsy-based studies, VM was reported in approximately 20-50% of patients with AIDS. It manifests in various says, mainly presenting as a painless spastic paraparesis with a sensory ataxia. We present a rare case of VM after bone marrow transplantation (BMT) in a patient without AIDS. A 50-year-old man developed weakness in the lower legs, leg muscle atrophy, and difficulty in walking 86 days after BMT. The patient died from septic shock on day 309. The autopsy revealed intralamellar vacuolation in the spinal white matter, which was compatible with VM.