Journal of perinatology : official journal of the California Perinatal Association · 2002
QTc interval in infants receiving cisapride.
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Chhina Satbir, Peverini Ricardo L, Deming Douglas D, Hopper Andrew O, Hashmi Aijaz, Vyhmeister Nidia R
Аннотация
OBJECTIVE: To examine the effect of cisapride on the corrected QT (QTc) interval in infants over a 14-day period.
STUDY DESIGN: A prospective cohort study of infants receiving cisapride (0.8 mg/kg per day). Twelve-lead electrocardiograms were obtained before and 3, 5, 7, and 14 days after cisapride initiation.
RESULTS: Fifty infants completed the study; none had arrhythmias. Fifteen of 50 infants (30%) developed QTc interval > or =450 msec; QTc interval normalized in 13 of 15 infants. Infants with QTc interval on day 3 > or =2 standard deviations above the mean baseline QTc interval (401+40 msec) were more likely to develop prolonged QTc interval (p<0.0001).
CONCLUSION: QTc interval prolongation was noted in 30% of infants. Subsequently, the majority of those infants had QTc interval normalization by day 14 of cisapride therapy. QTc interval 3 days following cisapride initiation may identify infants at risk for transient QTc interval prolongation. With appropriate monitoring, hospitalized infants receiving cisapride may have improved gastrointestinal motility without cardiac morbidity.
STUDY DESIGN: A prospective cohort study of infants receiving cisapride (0.8 mg/kg per day). Twelve-lead electrocardiograms were obtained before and 3, 5, 7, and 14 days after cisapride initiation.
RESULTS: Fifty infants completed the study; none had arrhythmias. Fifteen of 50 infants (30%) developed QTc interval > or =450 msec; QTc interval normalized in 13 of 15 infants. Infants with QTc interval on day 3 > or =2 standard deviations above the mean baseline QTc interval (401+40 msec) were more likely to develop prolonged QTc interval (p<0.0001).
CONCLUSION: QTc interval prolongation was noted in 30% of infants. Subsequently, the majority of those infants had QTc interval normalization by day 14 of cisapride therapy. QTc interval 3 days following cisapride initiation may identify infants at risk for transient QTc interval prolongation. With appropriate monitoring, hospitalized infants receiving cisapride may have improved gastrointestinal motility without cardiac morbidity.
Предметные рубрики MeSH
Analysis of VarianceCisaprideCohort StudiesDose-Response Relationship, DrugDrug Administration ScheduleElectrocardiographyEsophageal Motility DisordersFemaleFollow-Up StudiesGastrointestinal MotilityHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleProbabilityProspective StudiesRisk AssessmentTreatment Outcome