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DOI 10.2217/fmb-2022-0224

Медицинская библиотека · Future microbiology · 2023

Antifungal activity of cisatracurium against fluconazole-resistant Candida isolates and its antibiofilm effects.

do Nascimento Francisca Ba, Valente Sá Lívia Ga, de Andrade Neto João B, Cabral Vitória Pf, Rodrigues Daniel S, Barbosa Amanda D, Moreira Lara Ea, Oliveira Leilson C, Silva Anderson, Lima Iri Sp, Silva Jacilene, Marinho Emmanuel S, Santos Hélcio S, Cavalcanti Bruno C, Morais Manoel O, Júnior Hélio Vn, Silva Cecília R

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Аннотация

Aim: To evaluate the antifungal activity of cisatracurium against Candida spp. resistant to fluconazole strains in planktonic and biofilm forms, in addition to determining its mechanism of action. Materials & methods: Antifungal activity and pharmacological interactions were determined using broth microdilution methods and the mechanism of action was evaluated by flow cytometry and molecular docking.

Results

Cisatracurium presented antifungal activity against Candida spp. planktonic cells due to alterations of mitochondrial transmembrane potential leading to cellular apoptosis in addition to interacting with important targets related to cellular respiration, membrane and cell wall evidenced by molecular docking. Furthermore, the drug both prevented biofilm formation and impaired mature biofilms.

Conclusion

Cisatracurium exhibits potential antifungal activity against Candida spp.

Для цитирования: do Nascimento Francisca Ba, Valente Sá Lívia Ga, de Andrade Neto João B, Cabral Vitória Pf, Rodrigues Daniel S, Barbosa Amanda D, Moreira Lara Ea, Oliveira Leilson C, Silva Anderson, Lima Iri Sp, Silva Jacilene, Marinho Emmanuel S, Santos Hélcio S, Cavalcanti Bruno C, Morais Manoel O, Júnior Hélio Vn, Silva Cecília R. Antifungal activity of cisatracurium against fluconazole-resistant Candida isolates and its antibiofilm effects.. Future microbiology. 2023. DOI: 10.2217/fmb-2022-0224.

Предметные рубрики MeSH

Antifungal AgentsFluconazoleCandidaMolecular Docking SimulationBiofilmsMicrobial Sensitivity TestsDrug Resistance, FungalAtracurium
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