Congenital generalized epidermolysis bullosa in a calf.

Epidermolysis bullosa is reported in a newborn calf. The disorder was lethal due to the large extension and severity of the skin lesions. Histopathologically, the defect was characterized by suprabasilar clefts located in stratum spinosum. In large areas, most epidermal layers were lost exposing stratum basale or even dermis. The basal membrane seemed normal. The disorder shared features with previous reported cases of both epidermolysis bullosa and familial acantholysis. The aetiology was not determined.