Cardiovascular drugs and therapy · 2024
Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhou Xianpeng, Wang Hao, Yan Biao, Nie Xinwen, Chen Qingjie, Yang Xiaosong, Lei Min, Guo Xiying, Ouyang Changhan, Ren Zhanhong
Аннотация
OBJECTIVE: Cardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.
METHODS: A comprehensive review was conducted using the literature researches.
RESULTS AND DISCUSSION: Many ferroptosis-targeted compounds and ferroptosis-related genes may be prospective targets for treating CVDs and our review provides a solid foundation for further studies about the detailed pathological mechanisms of CVDs.
CONCLUSION: There are challenges and limitations about the translation of ferroptosis-targeted potential therapies from experimental research to clinical practice. It warrants further exploration to pursure safer and more effective ferroptosis-targeted thereapeutic approaches for CVDs.
METHODS: A comprehensive review was conducted using the literature researches.
RESULTS AND DISCUSSION: Many ferroptosis-targeted compounds and ferroptosis-related genes may be prospective targets for treating CVDs and our review provides a solid foundation for further studies about the detailed pathological mechanisms of CVDs.
CONCLUSION: There are challenges and limitations about the translation of ferroptosis-targeted potential therapies from experimental research to clinical practice. It warrants further exploration to pursure safer and more effective ferroptosis-targeted thereapeutic approaches for CVDs.