American journal of reproductive immunology (New York, N.Y. : 1989) · 2003
Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Varla-Leftherioti Marighoula, Spyropoulou-Vlachou Maria, Niokou Demetra, Keramitsoglou Theodora, Darlamitsou Areti, Tsekoura Christina, Papadimitropoulos Miltiadis, Lepage Virginia, Balafoutas Christos, Stavropoulos-Giokas Catherine
Аннотация
PROBLEM: Natural killer (NK) cell receptors (NKRs) have been suggested to protect trophoblast, but their function at the fetomaternal interface remains unknown. To investigate if the outcome of pregnancy depends on women's NKRs, we studied the NKR repertoire in couples with recurrent spontaneous abortions (RSA).
METHODS: Twenty-six childless couples with > or = 2 abortions, characterized by alloimmune abnormalities, and 26 control couples were genotyped for five killer immunoglobulin-like receptors (KIR) and two CD94/NKG receptors, known to have as ligands human leukocyte antigen (HLA) class I molecules with trophoblastic expression: inhibitory 2DL1,2,3 and activating 2DS1,4 KIRs, inhibitory NKG2A and activating NKG2C. Detected repertoires of women and partners were compared between the two groups.
RESULTS: Less aborters than controls were found to have all three inhibitory KIRs (30.77% versus 69.23%, P = 0.01), some of them had only one inhibitory KIR (19.23% versus 3.85%, P = 0.08) and most of them were lacking inhibitory KIRs possessed by their husbands (57.69% versus 15.38%, P = 0.001).
CONCLUSIONS: Women with alloimmune abortions have a limited inhibiting KIR repertoire and such miscarriages may occur because trophoblastic HLA class I molecules are recognized by decidual NK cells lacking the appropriate inhibitory KIRs.
METHODS: Twenty-six childless couples with > or = 2 abortions, characterized by alloimmune abnormalities, and 26 control couples were genotyped for five killer immunoglobulin-like receptors (KIR) and two CD94/NKG receptors, known to have as ligands human leukocyte antigen (HLA) class I molecules with trophoblastic expression: inhibitory 2DL1,2,3 and activating 2DS1,4 KIRs, inhibitory NKG2A and activating NKG2C. Detected repertoires of women and partners were compared between the two groups.
RESULTS: Less aborters than controls were found to have all three inhibitory KIRs (30.77% versus 69.23%, P = 0.01), some of them had only one inhibitory KIR (19.23% versus 3.85%, P = 0.08) and most of them were lacking inhibitory KIRs possessed by their husbands (57.69% versus 15.38%, P = 0.001).
CONCLUSIONS: Women with alloimmune abortions have a limited inhibiting KIR repertoire and such miscarriages may occur because trophoblastic HLA class I molecules are recognized by decidual NK cells lacking the appropriate inhibitory KIRs.
Предметные рубрики MeSH
Abortion, HabitualAntigens, CDFamily CharacteristicsFemaleGenotypeHLA AntigensHistocompatibility Antigens Class IHumansKiller Cells, NaturalLectins, C-TypeMaleNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DPolymerase Chain ReactionPregnancyReceptors, ImmunologicReceptors, KIRReceptors, KIR2DL1Receptors, Natural Killer CellTrophoblasts