[Cytogenetic analysis of hypophyseal adenoma. Study of 9 cases and review of the literature].

INTRODUCTION

To the best of our knowledge, no specific chromosomal abnormalities have been found in the literature in pituitary adenomas. In the present study, we investigated 9 cases of pituitary adenoma and reviewed the current literature.

MATERIALS AND

METHODS

Nine cases of pituitary adenoma have been studied with immunohistochemistry and cytogenetic using short-term cultures.

RESULTS

All tumors had a normal karyotype. Three cases were clinically non-secreting adenomas, three cases produced prolactin, two showed growth hormone production and one thyroid-stimulating hormone. One of the cases showed dural invasion.

CONCLUSIONS

We compared our results with those published in the current literature. It appears that pituitary adenomas do not have specific numerical and structural abnormalities and mostly show a normal karyotype.