Journal of cataract and refractive surgery · 1998
Corneal topography in Ehlers-Danlos syndrome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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McDermott M L, Holladay J, Liu D, Puklin J E, Shin D H, Cowden J W
Аннотация
PURPOSE: To assess the use of corneal topography in conjunction with slitlamp biomicroscopy and retinoscopy to diagnose keratoconus in a large group of patients with Ehlers-Danlos syndrome (EDS).
SETTING: Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA.
METHODS: Thirty-six patients (72 eyes) with genetically typed EDS had slitlamp biomicroscopy, retinoscopy, and videokeratography with the EyeSys instrument. The presence or absence of slitlamp keratoconus findings was correlated to a presumptive diagnosis based on corneal topography using derived topographic indexes associated with keratoconus. These topographic indexes included central corneal power, (CCP), difference in CCP, inferosuperior asymmetry (I-S) value, and asphericity (Q). Axial and profile difference maps were generated and analyzed for findings suggestive of keratoconus.
RESULTS: In 72 eyes, no keratoconus was found using slitlamp biomicroscopy. No eye had an I-S value greater than 1.60 diopters (D), 2 eyes had a CCP greater than 46.50 D, and 2 eyes had a Q value less than -1.00. Eight of 36 pairs of eyes had an intereye CCP greater than 0.92 D. In both eyes of the patient with Q values less than -1.00 the profile difference maps were mildly abnormal.
CONCLUSIONS: Slitlamp biomicroscopy of the cornea was unremarkable in all patients. Only 1 patient had Q values and profile difference maps that were mildly suggestive of keratoconus. Even after adding topography to the examination, it appears that keratoconus in a known population of patients with EDS remains rare.
SETTING: Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA.
METHODS: Thirty-six patients (72 eyes) with genetically typed EDS had slitlamp biomicroscopy, retinoscopy, and videokeratography with the EyeSys instrument. The presence or absence of slitlamp keratoconus findings was correlated to a presumptive diagnosis based on corneal topography using derived topographic indexes associated with keratoconus. These topographic indexes included central corneal power, (CCP), difference in CCP, inferosuperior asymmetry (I-S) value, and asphericity (Q). Axial and profile difference maps were generated and analyzed for findings suggestive of keratoconus.
RESULTS: In 72 eyes, no keratoconus was found using slitlamp biomicroscopy. No eye had an I-S value greater than 1.60 diopters (D), 2 eyes had a CCP greater than 46.50 D, and 2 eyes had a Q value less than -1.00. Eight of 36 pairs of eyes had an intereye CCP greater than 0.92 D. In both eyes of the patient with Q values less than -1.00 the profile difference maps were mildly abnormal.
CONCLUSIONS: Slitlamp biomicroscopy of the cornea was unremarkable in all patients. Only 1 patient had Q values and profile difference maps that were mildly suggestive of keratoconus. Even after adding topography to the examination, it appears that keratoconus in a known population of patients with EDS remains rare.