Association between expression of long noncoding RNAs in placenta and pregnancy features.

Aim: The contribution of long noncoding RNAs (lncRNAs) has been highlighted in a variety of human disorders including cancer and placenta-associated conditions.

Methods

We evaluated expression of CCAT2, UCA1, FAS-AS1 and OIP5-AS1 lncRNAs in placenta samples obtained from normal and intrauterine growth restriction pregnancies.

Results

There was no significant difference in expression of these lncRNAs between cases and controls. A significant association was found between CCAT2 expression and gravidity/parity. CCAT2 expression was higher in cases with abortion history. Cases who received folic acid had lower expression of this lncRNA.

Conclusion

The current study provides evidences for association between expression of CCAT2 and clinical determinants of placenta function. Future studies are needed to elaborate the underlying mechanism.