Медицинская библиотека · Hypertension in pregnancy · 2023

MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan.

Mahmood Sadia, Younus Amna, Nathaniel Sammar, Younas Hooria

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Аннотация

OBJECTIVES

This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan.

METHODS

A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping MTHFR A1298C polymorphism by using the tetra-primer amplification refractory mutation system (ARMS) PCR. The Genotypic and allelic assessments were performed using various statistical techniques.

RESULTS

The AC genotype and C allele of MTHFR A1298C were found to be associated with decreased risk of PE (odds ratio [OR]: 0.31, risk ratio [RR]: 0.58, p = 0.01), and (odds ratio [OR]: 0.49, risk ratio [RR]: 0.61, p = 0.04), respectively.

CONCLUSION

In conclusion, genetic polymorphism A1298C in MTHFR may pose a protective effect in the studied population.

Для цитирования: Mahmood Sadia, Younus Amna, Nathaniel Sammar, Younas Hooria. MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan.. Hypertension in pregnancy. 2023. DOI: 10.1080/10641955.2023.2187621.

Предметные рубрики MeSH

Female Humans Pregnancy Case-Control Studies Genetic Predisposition to Disease Genotype Methylenetetrahydrofolate Reductase (NADPH2)Pakistan Polymorphism, Single Nucleotide Pre-Eclampsia

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