Effects of Different Concentrations of BSA on In Vitro Corrosion Behavior of Pure Zinc in Artificial Plasma.

When medical metallic materials are implanted in the body and come into contact with the body fluid environment, proteins will be rapidly adsorbed on the surface and affect the corrosion process of the material. Currently, there is no uniform understanding of the effect of protein adsorption on the corrosion behavior of materials due to the limitations of the nature of metal materials, protein concentrations, and different media environments. The effect of various bovine serum albumin (BSA) concentrations in artificial plasma (AP) on the corrosion behavior of pure Zn during 14 days of immersion was investigated in this research. The corrosion rate of pure Zn was slowed down by the addition of BSA, and the decelerating effect of lower protein concentration on the corrosion rate of Zn was more significant in the initial stage of immersion. With prolonging the immersion time, the corrosion rate of pure Zn in different media slowed down and stabilized, and the corrosion rates of pure Zn showed a decreasing trend with an increase of BSA concentration. Furthermore, the Langmuir adsorption isotherm model was utilized to study the relationship between the BSA concentration and corrosion behavior of pure Zn and to analyze the role of proteins in the degradation mechanism of pure Zn. This work could be useful for further exploration of potential clinical applications of zinc alloys.