Journal of epidemiology and community health · 2018
Paternal smoking and spontaneous abortion: a population-based retrospective cohort study among non-smoking women aged 20-49 years in rural China.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wang Long, Yang Ying, Liu Fangchao, Yang Aimin, Xu Qin, Wang Qiaomei, Shen Haiping, Zhang Yiping, Yan Donghai, Peng Zuoqi, He Yuan, Wang Yuanyuan, Xu Jihong, Zhao Jun, Zhang Hongguang, Zhang Ya, Dai Qiaoyun, Ma Xu
Аннотация
BACKGROUND: To comprehensively evaluate the association of paternal smoking and spontaneous abortion.
METHODS: We conducted a population-based retrospective cohort study among 5 770 691 non-smoking rural Chinese women, along with their husbands, participating in the National Free Pre-Pregnancy Checkups Project, regarding outcome events that occurred in 2010-2016. The main outcome was spontaneous abortion (SA). Multivariable logistic regression was used to estimate OR and 95% CI, and restricted cubic spline was used to estimate the non-linear relationship.
RESULTS: The multivariable-adjusted OR of exposure to paternal smoking for SA was 1.17 (95% CI 1.16 to 1.19), compared with women without exposure to paternal smoking; and corresponding OR of exposure to preconception paternal smoking for SA was 1.11 (95% CI 1.08 to 1.14), compared with women without exposure to preconception paternal smoking. The ORs of preconception paternal smoking also increased with increases in paternal smoking (pnonlinear<0.05, almost linearly shaped) and preconception paternal smoking (pnonlinear>0.05). In addition, periconception paternal smoking cessation was associated with an 18% (15%-22%) lower risk of SA.
CONCLUSION: Paternal smoking was associated with SA. The importance of tobacco control, specifically pertaining to paternal smoking, should be emphasised during preconception and pregnancy counselling.
METHODS: We conducted a population-based retrospective cohort study among 5 770 691 non-smoking rural Chinese women, along with their husbands, participating in the National Free Pre-Pregnancy Checkups Project, regarding outcome events that occurred in 2010-2016. The main outcome was spontaneous abortion (SA). Multivariable logistic regression was used to estimate OR and 95% CI, and restricted cubic spline was used to estimate the non-linear relationship.
RESULTS: The multivariable-adjusted OR of exposure to paternal smoking for SA was 1.17 (95% CI 1.16 to 1.19), compared with women without exposure to paternal smoking; and corresponding OR of exposure to preconception paternal smoking for SA was 1.11 (95% CI 1.08 to 1.14), compared with women without exposure to preconception paternal smoking. The ORs of preconception paternal smoking also increased with increases in paternal smoking (pnonlinear<0.05, almost linearly shaped) and preconception paternal smoking (pnonlinear>0.05). In addition, periconception paternal smoking cessation was associated with an 18% (15%-22%) lower risk of SA.
CONCLUSION: Paternal smoking was associated with SA. The importance of tobacco control, specifically pertaining to paternal smoking, should be emphasised during preconception and pregnancy counselling.