The Journal of clinical endocrinology and metabolism · 2002
Expression of PDS/Pds, the Pendred syndrome gene, in endometrium.
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Suzuki Koichi, Royaux Ines E, Everett Lorraine A, Mori-Aoki Atsumi, Suzuki Sayuri, Nakamura Kazuaki, Sakai Takafumi, Katoh Ryohei, Toda Shuji, Green Eric D, Kohn Leonard D
Аннотация
Expression of the Pendred syndrome gene (PDS/Pds) is thought to be responsible for the iodide transport in the thyroid as well as the formation and function of the inner ear. Its mRNA is also expressed in the kidney and placenta. We report here that PDS and its encoded protein (pendrin) are also expressed in the endometrium. The RNA levels of rat PDS in the endometrium and kidney were much higher than those of the thyroid, opposite of the pattern of RNA expression in humans. In human endometrium, pendrin localization changed from the basal to apical surfaces of the epithelium during progression of the menstrual cycle. This suggests a possible role for pendrin in cationic ion transport required to maintain the physiological function of the endometrium. Since there is no evidence of endometrial abnormalities in patients with Pendred syndrome, it suggests the existence of a compensatory mechanisms for pendrin's function in the uterus.