Clinical value of combined detection of procalcitonin, D-dimer and fibrinogen in the evaluation of children with sepsis.

OBJECTIVE

To evaluate the clinical value of combined detection of procalcitonin (PCT), D-dimer (DD) and fibrinogen (FIB) in the evaluation of children with sepsis.

METHOD: This was a retrospective study. Eighty children with sepsis hospitalized in Baoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University from January 2022 to January 2024 were selected as the experimental group, 40 non-sepsis infected children were selected and included in the control group. Ten milliliter of elbow vein blood was collected from all children after admission, and relevant tests were completed within one hour. The levels of PCT, DD and FIB were analyzed and compared between the two groups.

RESULTS

The levels of PCT, FIB, and DD were significantly increased in children with sepsis compared with those in the common infection group, and the levels of these biomarkers were significantly increased in the severe sepsis group compared with those in the mild sepsis group, with statistical significances; the favorable diagnostic efficacy of PCT alone for sepsis. The AUC of combined detection of the three indicators were higher than those of PCT, DD, and FIB alone; PCT was significantly positively correlated with CRP, DD, and FIB, with a slightly weaker correlation with WBC.

CONCLUSION

PCT, DD and FIB may be helpful for the diagnosis and assessment of sepsis, and PCT alone has a favorable diagnostic efficacy for sepsis and is correlated with other inflammatory factors. Combined detection of PCT, DD and FIB may be considered in the diagnosis and prognosis evaluation of pediatric sepsis in clinical practice.