Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025
Ionized Calcium Before Venous Bubble Trap Strongly Affects Coagulation When Using Calcium-Containing Dialysate in Regional Citrate Anticoagulation for Intermittent Hemodialysis: A Real-World Prospective Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ai Zhen, Luo Lijun, Li Wenhao, Wu Haishan, Zhao Lian, Wang Raoping, Zhang Dihua, Wen Suiqin, Xu Yuanwen
Аннотация
INTRODUCTION: Regional citrate anticoagulation (RCA) is highly recommended as an anticoagulation method for intermittent hemodialysis (IHD) in patients at high bleeding risk. Few studies have investigated the effect of ionized calcium (iCa) concentration at different pipeline points on circuit clotting in RCA using calcium-containing dialysate.
METHODS: This prospective study included 185 IHD sessions treated with a two-stage RCA protocol. Ionized calcium levels were measured at different pipeline points. The primary endpoint was severe clotting in the extracorporeal circulation circuit (ECC).
RESULTS: Sessions with severe circuit clotting showed higher platelet counts, shorter activated partial thromboplastin time, greater dialyzer surface areas, and higher iCa concentrations around venous bubble trap (VBT). Cox regression models revealed that iCa concentration before VBT (per 0.10 mmol/L, hazard ratio (HR) = 1.54, p = 0.006) and baseline platelet count (HR = 1.01, p = 0.02) were strongly associated with severe circuit clotting.
CONCLUSION: The iCa concentration before VBT could serve as a key indicator of anticoagulant efficacy in RCA with calcium-containing dialysate.
METHODS: This prospective study included 185 IHD sessions treated with a two-stage RCA protocol. Ionized calcium levels were measured at different pipeline points. The primary endpoint was severe clotting in the extracorporeal circulation circuit (ECC).
RESULTS: Sessions with severe circuit clotting showed higher platelet counts, shorter activated partial thromboplastin time, greater dialyzer surface areas, and higher iCa concentrations around venous bubble trap (VBT). Cox regression models revealed that iCa concentration before VBT (per 0.10 mmol/L, hazard ratio (HR) = 1.54, p = 0.006) and baseline platelet count (HR = 1.01, p = 0.02) were strongly associated with severe circuit clotting.
CONCLUSION: The iCa concentration before VBT could serve as a key indicator of anticoagulant efficacy in RCA with calcium-containing dialysate.