[Molecular epidemiology peculiarities in forming of antimicrobial resistance of Streptococcus pneumonia strains, isolated in elderly patients.].

Despite of advances in diagnostics and treatment of respiratory tract infections, respiratory tract bacterial infections morbidity is still remaining the significant problem of modern medicine. Moreover, microbiological diagnostics of etiology identified in community-acquired aged patients pathogens spectrum allows to consider the main causative agent Streptococcus pneumoniae. Antimicrobial agents resistance of this pathogen is the actual problem in treatment of all forms of pneumococcal infections and is till one of the factor defining the epidemiology significance of pneumococcal infection as the source of forming of epidemiological clone. Aim of our study was to estimate the peculiarities of antimicrobial agents resistance of S. pneumoniae strains, isolated in aged patients with diagnosis of community-acquired pneumonia and bronchitis. There were used such methods as disco-diffusion method, method of minimum inhibitory concentration, strains were isolated from patients with community-acquired pneumonia, bronchitis, and carriers, then there were conducted molecular epidemiology monitoring of the isolated strains to the main antimicrobial agents resistance determinants. There were revealed that in all groups multidrugresistance had been caused with the similar process of forming to macrolides. In colculsion, the gained results allows to consider that in population causing invasive and non-invasive forms there are the same processes of antimicrobial agents resistance to macrolides.