ULTRASTRUCTURAL FEATURES OF THE REARRANGEMENT OF CELLS OF THE HEMATOTESTICULAR BARRIER AND SPERMATOGENIC EPITHELIUM OF THE RATS TESTICLES AFTER INTRODUCTION OF HIGH DOSES OF PREDNISOLONE.

A feature of recent decades is the gradual increase in the level of male infertility, one of the important causes of which, of course, is endocrine dysfunction of various origins. Therefore, the aim of the study was to establish the features of the rearrangement of the testicle's cellular elements of white rats with the introduction of high doses of prednisolone. An ultrastructural study was carried out on 42 male rats. It has been established that long-term introduction of high doses of prednisolone promotes the activation of spermatogenesis with a progressive increase in immature forms of germ cells and a simultaneous decrease in the specific number of mature spermatozoa. Activation of spermatogenesis occurs against the background of increased blood circulation in the testicles with an increase in the blood supply to their vessels, especially in the early period (7-14 days from the start of use), which may be a consequence of the direct effects of prednisolone stimulating blood circulation. In the long term (14-28 days) there is a decrease in the throughput of small arteries and arterioles against the background of venous stasis, as well as the rate of activation of spermatogenesis, which may be a reaction to the overload of the capillary bed of the testicles and cause further development of organ's ischemia with it.