[The expression of aromatase P450 in the mammary gland of hypertrophic breast].

OBJECTIVE

To investigate the expression of aromatase P450 in the mammary gland of hypertrophic breast.

METHODS

The expression of aromatase P450 in the mammary gland was detected by SP immunohistochemistry in 28 cases of hypertrophic breasts and 12 cases of normal volume breasts. The results were analysed by SPSS 13.0, and comparison among groups was performed by Fisher's exact test.

RESULTS

The positive expression rate of aromatase P450 in hypertrophic group was 39.29%, while there was no positive expression in normal group, showing a significant difference between the two groups (P < 0.05). There was no significant difference between the gland hyperplasia group and adipose hyperplasia group (P > 0.05). There were also no significant difference between the groups with different lactation history or different extent of hypertrophy and mastocytosis (P > 0.05).

CONCLUSIONS

Overexpression of aromatase P450 in mammary gland may be related to the development of hypertrophic breast.