Expert opinion on biological therapy · 2008
Genetic basis for kidney cancer: opportunity for disease-specific approaches to therapy.
СтатьяResearch Support, N.I.H., IntramuralСистематический обзорНазвание и аннотация: Перевод в очереди
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Pfaffenroth Elizabeth Cartwright, Linehan W Marston
Аннотация
BACKGROUND: Kidney cancer is not a homogenous entity; it is comprised of many different tumor types, with different biologies and molecular mechanisms leading to disease and therefore different treatment approaches.
OBJECTIVE: To describe the genetic basis and biochemical pathways underlying inherited forms of renal cancer, specifically in four described syndromes (von Hippel-Lindau [VHL], hereditary papillary renal cancer [HPRC], Birt-Hogg-Dubé [BHD] and hereditary leiomyomatosis renal cell carcinoma [HLRCC]), and to elucidate how the understanding of these diseases enables the possibility of disease-specific approaches to therapy.
METHODS: A systematic review of the published literature on inherited and sporadic forms of renal cancer was performed.
CONCLUSION: Understanding of the biology and mechanisms of different forms of kidney cancer provides an opportunity for development of new treatment options.
OBJECTIVE: To describe the genetic basis and biochemical pathways underlying inherited forms of renal cancer, specifically in four described syndromes (von Hippel-Lindau [VHL], hereditary papillary renal cancer [HPRC], Birt-Hogg-Dubé [BHD] and hereditary leiomyomatosis renal cell carcinoma [HLRCC]), and to elucidate how the understanding of these diseases enables the possibility of disease-specific approaches to therapy.
METHODS: A systematic review of the published literature on inherited and sporadic forms of renal cancer was performed.
CONCLUSION: Understanding of the biology and mechanisms of different forms of kidney cancer provides an opportunity for development of new treatment options.
Предметные рубрики MeSH
Antineoplastic AgentsCarcinoma, Renal CellDrug DesignFumarate HydrataseGenes, Tumor SuppressorGenetic Predisposition to DiseaseHumansKidney NeoplasmsLeiomyomatosisNeoplasm ProteinsNeoplasms, Multiple PrimaryNeoplastic Syndromes, HereditaryProto-Oncogene ProteinsProto-Oncogene Proteins c-metProto-OncogenesReceptors, Growth FactorTumor Suppressor ProteinsVascular Endothelial Growth Factor AVon Hippel-Lindau Tumor Suppressor Proteinvon Hippel-Lindau Disease