Journal of perinatology : official journal of the California Perinatal Association · 2006
Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth.
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Jegatheesan P, Keller R L, Hawgood S
Аннотация
OBJECTIVE: To compare the incidence of chronic lung disease (CLD) in extremely low birth weight (ELBW, < or =1000 g) infants before and after the introduction of early, preferential application of nasal continuous airway pressure (NCPAP) utilizing a variable flow delivery system.
STUDY DESIGN: A retrospective cohort study of ELBW infants 2 years prior to (Pre-early NCPAP, n=96) and 2 years following (Early NCPAP, n=75) the initiation of an early NCPAP policy.
RESULTS: There were no significant changes (Pre-early NCPAP vs Early NCPAP) in the incidences of CLD (35 vs 33%, P=0.81) or CLD or death (50 vs 43%, P=0.34). Infants in the Early NCPAP group weaned off mechanical ventilation and supplemental oxygen more rapidly than infants in the Pre-early NCPAP group (hazard ratio (HR) 1.80, P=0.002 and HR 1.69, P=0.01).
CONCLUSION: A policy of early NCPAP has not decreased the incidence of CLD despite a decrease in time to successful tracheal extubation.
STUDY DESIGN: A retrospective cohort study of ELBW infants 2 years prior to (Pre-early NCPAP, n=96) and 2 years following (Early NCPAP, n=75) the initiation of an early NCPAP policy.
RESULTS: There were no significant changes (Pre-early NCPAP vs Early NCPAP) in the incidences of CLD (35 vs 33%, P=0.81) or CLD or death (50 vs 43%, P=0.34). Infants in the Early NCPAP group weaned off mechanical ventilation and supplemental oxygen more rapidly than infants in the Pre-early NCPAP group (hazard ratio (HR) 1.80, P=0.002 and HR 1.69, P=0.01).
CONCLUSION: A policy of early NCPAP has not decreased the incidence of CLD despite a decrease in time to successful tracheal extubation.
Предметные рубрики MeSH
Bronchopulmonary DysplasiaCohort StudiesConfidence IntervalsContinuous Positive Airway PressureFemaleFollow-Up StudiesHumansInfant, NewbornInfant, Very Low Birth WeightIntensive Care Units, NeonatalMaleOdds RatioProbabilityRespiratory Distress Syndrome, NewbornRetrospective StudiesRisk AssessmentSurvival RateTreatment Outcome