Transplantation proceedings · 2014
Association of IL-17F gene polymorphisms with renal transplantation outcome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Park H, Shin S, Park M H, Kim Y S, Ahn C, Ha J, Song E Y
Аннотация
OBJECTIVE: Although interleukin 17 (IL-17) has some roles in renal transplantation, the influence of IL-17 gene single-nucleotide polymorphisms (SNPs) on renal transplantation has not been studied.
METHODS: The associations of 5 IL-17F gene SNPs (-1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for -1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.
RESULTS: IL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).
CONCLUSION: IL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients.
METHODS: The associations of 5 IL-17F gene SNPs (-1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for -1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.
RESULTS: IL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).
CONCLUSION: IL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients.
Предметные рубрики MeSH
AllelesCase-Control StudiesCytokinesFemaleGene FrequencyGenotypeGraft RejectionGraft SurvivalHistocompatibility TestingHumansInflammationInterleukin-17Kidney Failure, ChronicKidney TransplantationMaleMultivariate AnalysisPolymerase Chain ReactionPolymorphism, Single NucleotideRepublic of KoreaRisk FactorsTreatment Outcome